human frozen tumour tissue micro-array (tma) slides Search Results


human frozen tumour tissue micro-array (tma) slides  (BioIVT Inc)
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BioIVT Inc human frozen tumour tissue micro-array (tma) slides
Human Frozen Tumour Tissue Micro Array (Tma) Slides, supplied by BioIVT Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
human frozen tumour tissue micro-array (tma) slides - by Bioz Stars, 2026-04
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human multiple organ tumour tissue microarray slides (bc00119)  (U.S Biomax Inc)
90
U.S Biomax Inc human multiple organ tumour tissue microarray slides (bc00119)
a, b, Proportion of all tumours harbouring gain of MYC but not PVT1 (blue), PVT1 but not MYC (orange) and MYC + PVT1 (green) in the Progenetix (left) and TCGA databases (right) (a) and among different cancer types in the TCGA database (b). c, Tissue <t>microarray</t> analysis showing nuclear expression of PVT1 (dark purple) and MYC (dark brown) in primary human tumours. Lower panels represent × 10 magnification of regions shown by arrow in the upper panel. d, Cartoons showing that stabilized mutant β-catenin (β-cat) upregulates MYC transcription through the recruitment of T-cell factor (TCF) in human colorectal cancer line HCT116. e, Schematic of CRISPR-mediated excision of PVT1 to obtain the ΔPVT1 allele. DNA sequence of a PCR amplicon containing the junction sequence of the deletion product is shown. f, Images of colonies formed by PVT1+ and ΔPVT1 HCT116 cells in soft agar assay (top). The insets are ×3 magnification of the areas marked in each plate. Quantification of the respective colonies (bottom, n = 3). g, Tumour volume measurements from xenograft transplants of PVT1+ and ΔPVT1 HCT116 cells. Bioluminescent imaging at 3, 7, 10, 13 and 17 days after inoculation (left). ΔPVT1 HCT116 inoculation at the left flank where the tumour failed to grow is designated by white circle (dashed). Mean tumour volumes are quantified (n = 6) (right). h, Western blot of MYC and GAPDH protein in three PVT1+ and ΔPVT1 HCT116 clones. Quantification of relative MYC protein levels in PVT11 and PVT1D HCT116 cells is shown (n = 3). i, Predicted outlook for an 8q24 cancer patient after inhibition of PVT1. Results are shown as mean ± s.e.m. (*P<0.05, **P<0.01, ***P<0.001, two-tailed Student’s t-test). Scale bar, 500 μm (c, top two rows of panels), 50 μm (c, bottom two rows of panels); error bars, s.e.m.
Human Multiple Organ Tumour Tissue Microarray Slides (Bc00119), supplied by U.S Biomax Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human multiple organ tumour tissue microarray slides (bc00119)/product/U.S Biomax Inc
Average 90 stars, based on 1 article reviews
human multiple organ tumour tissue microarray slides (bc00119) - by Bioz Stars, 2026-04
90/100 stars
  Buy from Supplier

Image Search Results


a, b, Proportion of all tumours harbouring gain of MYC but not PVT1 (blue), PVT1 but not MYC (orange) and MYC + PVT1 (green) in the Progenetix (left) and TCGA databases (right) (a) and among different cancer types in the TCGA database (b). c, Tissue microarray analysis showing nuclear expression of PVT1 (dark purple) and MYC (dark brown) in primary human tumours. Lower panels represent × 10 magnification of regions shown by arrow in the upper panel. d, Cartoons showing that stabilized mutant β-catenin (β-cat) upregulates MYC transcription through the recruitment of T-cell factor (TCF) in human colorectal cancer line HCT116. e, Schematic of CRISPR-mediated excision of PVT1 to obtain the ΔPVT1 allele. DNA sequence of a PCR amplicon containing the junction sequence of the deletion product is shown. f, Images of colonies formed by PVT1+ and ΔPVT1 HCT116 cells in soft agar assay (top). The insets are ×3 magnification of the areas marked in each plate. Quantification of the respective colonies (bottom, n = 3). g, Tumour volume measurements from xenograft transplants of PVT1+ and ΔPVT1 HCT116 cells. Bioluminescent imaging at 3, 7, 10, 13 and 17 days after inoculation (left). ΔPVT1 HCT116 inoculation at the left flank where the tumour failed to grow is designated by white circle (dashed). Mean tumour volumes are quantified (n = 6) (right). h, Western blot of MYC and GAPDH protein in three PVT1+ and ΔPVT1 HCT116 clones. Quantification of relative MYC protein levels in PVT11 and PVT1D HCT116 cells is shown (n = 3). i, Predicted outlook for an 8q24 cancer patient after inhibition of PVT1. Results are shown as mean ± s.e.m. (*P<0.05, **P<0.01, ***P<0.001, two-tailed Student’s t-test). Scale bar, 500 μm (c, top two rows of panels), 50 μm (c, bottom two rows of panels); error bars, s.e.m.

Journal: Nature

Article Title: PVT1 dependence in cancer with MYC copy-number increase

doi: 10.1038/nature13311

Figure Lengend Snippet: a, b, Proportion of all tumours harbouring gain of MYC but not PVT1 (blue), PVT1 but not MYC (orange) and MYC + PVT1 (green) in the Progenetix (left) and TCGA databases (right) (a) and among different cancer types in the TCGA database (b). c, Tissue microarray analysis showing nuclear expression of PVT1 (dark purple) and MYC (dark brown) in primary human tumours. Lower panels represent × 10 magnification of regions shown by arrow in the upper panel. d, Cartoons showing that stabilized mutant β-catenin (β-cat) upregulates MYC transcription through the recruitment of T-cell factor (TCF) in human colorectal cancer line HCT116. e, Schematic of CRISPR-mediated excision of PVT1 to obtain the ΔPVT1 allele. DNA sequence of a PCR amplicon containing the junction sequence of the deletion product is shown. f, Images of colonies formed by PVT1+ and ΔPVT1 HCT116 cells in soft agar assay (top). The insets are ×3 magnification of the areas marked in each plate. Quantification of the respective colonies (bottom, n = 3). g, Tumour volume measurements from xenograft transplants of PVT1+ and ΔPVT1 HCT116 cells. Bioluminescent imaging at 3, 7, 10, 13 and 17 days after inoculation (left). ΔPVT1 HCT116 inoculation at the left flank where the tumour failed to grow is designated by white circle (dashed). Mean tumour volumes are quantified (n = 6) (right). h, Western blot of MYC and GAPDH protein in three PVT1+ and ΔPVT1 HCT116 clones. Quantification of relative MYC protein levels in PVT11 and PVT1D HCT116 cells is shown (n = 3). i, Predicted outlook for an 8q24 cancer patient after inhibition of PVT1. Results are shown as mean ± s.e.m. (*P<0.05, **P<0.01, ***P<0.001, two-tailed Student’s t-test). Scale bar, 500 μm (c, top two rows of panels), 50 μm (c, bottom two rows of panels); error bars, s.e.m.

Article Snippet: Tissue microarray analysis Human multiple organ tumour tissue microarray slides (BC00119) were obtained from US Biomax.

Techniques: Microarray, Expressing, Mutagenesis, CRISPR, Sequencing, Amplification, Soft Agar Assay, Imaging, Western Blot, Clone Assay, Inhibition, Two Tailed Test